Introduction to Physical biochemistry: Biochemical properties of water, molecular structure and ionization of water, SI units, concentrations, Keqs, ionic strength, kW, pH, pOH, Ka, Kb the pH scale, . Henderson Hasselbalch equation, titration curves, buffers, buffer capacity, and importance of buffers in the body. Additionally, it also deals with bioenergetics and laws of thermodynamics. Laws of thermodynamics, high energy bonds, exergonic and endergonic reactions, activation energy, coupling of energy.